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Glucose is the energy that fuels cells, and the body likes to store glucose for later use. But too much glucose can contribute to obesity, and scientists have long wanted to understand what happens within a cell to tip the balance.

Researchers at UT Southwestern Medical Center have identified two proteins in a fetus’ lungs responsible for initiating the labor process, providing potential new targets for preventing preterm birth.

A team of UT Southwestern researchers is making headway in unlocking the function of an enzyme complex that, when dysregulated in humans, is widely associated with developmental disorders and cancers, such as blood, prostate, and breast cancers, as well as childhood glioblastoma.

A single protein can reverse the developmental clock on adult brain cells called astrocytes, morphing them into stem-like cells that produce neurons and other cell types, UT Southwestern researchers report in a PNAS study.

A UT Southwestern research team has generated biological structures that resemble blastocysts, the structures that form from the early development of fertilized eggs in mammals, using previously established human embryonic stem cells derived from embryos donated for research and human-induced pluripotent

Using technology they developed, UT Southwestern Medical Center researchers have identified a previously unknown role of a certain class of proteins: as regulators of gene activity and RNA processing.

UT Southwestern Medical Center stem cell and developmental biologists and colleagues have developed a method to produce bovine blastoids, a crucial step in replicating embryo formation in the lab that could lead to the development of new reproductive technologies for cattle breeding.

Scientists from the Children’s Medical Center Research Institute at UT Southwestern (CRI) have developed an innovative system to identify and characterize the molecular components that control the activities of regulatory DNA sequences in the human genome.

The human heart is an intricate, complex organ and, like a car that starts sputtering, its function deteriorates for all sorts of reasons.

Ralf Kittler, with the Eugene McDermott Center for Human Growth and Development, and Dr. Robert Bachoo, with the Annette G. Strauss Center for Neuro-Oncology, are part of UT Southwestern's precision medicine campaign in neuro-oncology.